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Methyl donor supplementation prevents transgenerational amplification of obesity. Birth season and environmental influences on patterns of thymic growth in rural Gambian infants.
Maternal diabetes is also linked to changes in microbiome composition in the offspring, although future studies are critical to corroborate the association of maternal diet versus diabetes and the microbiome and immunity of the offspring Kaplan et al. Similarly, it has been reported that elevated blood pressure tracks from childhood into adulthood with eventual progression into essential hypertension [ 5 ]. However, we have argued elsewhere 24 that — in this environment — the most likely explanation for any long-term programming effect on the immune system is likely to be nutritional in origin, and our recent research has focused on elucidating the mechanisms linking the early life nutritional environment to long-term defects in functional immunity. Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine.
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Environmental influences on epigenetic profiles. In addition, acrylamide intake during pregnancy was significantly associated with higher weight growth in childhood.
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